Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Very low birth weight (< 1500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18233
R76472		 Rommel, 2022 Very low birthweight (<1500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: SSRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.95 [0.75;1.20] -/16,429   -/23,676 - 16,429
ref
S5461
R24125		 Levy, 2020 Birthweight < 5th centile throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 3.73 [0.75;18.54] C 7/82   2/82 9 82
ref
Total 2 studies 1.48 [0.42;5.21] 9 16,511
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rommel, 2022Rommel, 2022 0.95[0.75; 1.20]-16,42967%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Levy, 2020Levy, 2020 3.73[0.75; 18.54]98233%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 64% 1.48[0.42; 5.21]916,5110.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.48[0.42; 5.21]916,51164%NARommel, 2022 Levy, 2020 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.73[0.75; 18.54]982 -NALevy, 2020 1 unexposed, sickunexposed, sick 0.95[0.75; 1.20]-16,429 -NARommel, 2022 1 Tags Adjustment   - No  - No 3.73[0.75; 18.54]982 -NALevy, 2020 1   - Yes  - Yes 0.95[0.75; 1.20]-16,429 -NARommel, 2022 1 MatchedMatched 3.73[0.75; 18.54]982 -NALevy, 2020 1 Monotherapy   - no or not specified  - no or not specified 3.73[0.75; 18.54]982 -NALevy, 2020 1   - SSRI only  - SSRI only 0.95[0.75; 1.20]-16,429 -NARommel, 2022 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.95[0.75; 1.20]-16,429 -NARommel, 2022 1 All studiesAll studies 1.48[0.42; 5.21]916,51164%NARommel, 2022 Levy, 2020 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.73[0.75; 18.54]982 -NALevy, 2020 1 unexposed, sick controlsunexposed, sick controls 0.95[0.75; 1.20]-16,429 -NARommel, 2022 10.510.01.0