Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Extremely preterm (< 28 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12482
R47052		 Benevent, 2023 Extrem preterm (< 28 weeks) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: SSRI only 1.09 [0.35;3.41] C 3/1,638   245/146,034 248 1,638
ref
S18233
R76469		 Rommel, 2022 Extremely preterm (<28 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: SSRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.82 [0.53;1.25] -/16,429   -/23,676 - 16,429
ref
Total 2 studies 0.85 [0.57;1.27] 248 18,067
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Benevent, 2023Benevent, 2023 1.09[0.35; 3.41]2481,63812%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Rommel, 2022Rommel, 2022 0.82[0.53; 1.25]-16,42988%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.85[0.57; 1.27]24818,0670.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.85[0.57; 1.27]24818,0670%NABenevent, 2023 Rommel, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.09[0.35; 3.41]2481,638 -NABenevent, 2023 1 unexposed, sickunexposed, sick 0.82[0.53; 1.26]-16,429 -NARommel, 2022 1 Tags Adjustment   - No  - No 1.09[0.35; 3.41]2481,638 -NABenevent, 2023 1   - Yes  - Yes 0.82[0.53; 1.26]-16,429 -NARommel, 2022 1 Monotherapy   - SSRI only  - SSRI only 0.85[0.57; 1.27]24818,0670%NABenevent, 2023 Rommel, 2022 2 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.82[0.53; 1.26]-16,429 -NARommel, 2022 1 All studiesAll studies 0.85[0.57; 1.27]24818,0670%NABenevent, 2023 Rommel, 2022 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.35; 3.41]2481,638 -NABenevent, 2023 1 unexposed, sick controlsunexposed, sick controls 0.82[0.53; 1.26]-16,429 -NARommel, 2022 10.510.01.0