Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Abdominal wall defects

id	Study   Auto Benevent, 2023Nishigori, 2017Jordan, 2016Ban (Controls exposed to TCA), 2014Ban (Controls unexposed, disease free), 2014Ban (Controls unexposed, sick), 2014Jimenez-Solem (Controls unexposed, NOS), 2012Källén, 2007	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S12482 R47063	Benevent, 2023	Abdominal wall defects	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: SSRI only	1.85 [0.26;13.42] C	1/1,653   48/146,855	49	1,653		ref
S5364 R16333	Nishigori, 2017	Abdominal abnormality	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	2.37 [1.00;5.65]	7/172   1,207/95,822	1,214	172		ref
S5372 R18216	Jordan, 2016	Abdominal wall defects	3 months or more before pregnancy or1st trimester excluded	retrospective cohort (registry)	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	1.92 [1.13;3.24] excluded (exposition period)	15/12,962   275/506,155	290	12,962		ref
S5881 R14682	Ban (Controls exposed to TCA), 2014	Abdominal wall malformations	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: SSRI only	2.21 [0.11;42.85] C excluded (control group)	3/7,683   0/2,428	3	7,683		ref
S517 R14660	Ban (Controls unexposed, disease free), 2014	Abdominal wall malformations	1st trimester	retrospective cohort (claims database)	unexposed, disease free excluded	Adjustment: Yes Monotherapy: SSRI only	1.41 [0.43;4.59] excluded (control group)	3/7,683   69/325,294	72	7,683		ref
S6700 R18887	Ban (Controls unexposed, sick), 2014	Abdominal wall malformations	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: No Monotherapy: SSRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	2.62 [0.44;15.70] C	3/7,683   2/13,432	5	7,683		ref
S6013 R15476	Jimenez-Solem (Controls unexposed, NOS), 2012	Abdominal wall defects	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	1.04 [0.14;7.44]	1/4,183   -/843,797	-	4,183		ref
S495 R76918	Källén, 2007	Abdominal wall defect	early pregnancy	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SSRI only	1.16 [0.24;3.40]	3/6,555   316/873,876	319	6,555		ref
					Total	5 studies	1.87 [1.02;3.43]		1,587	20,246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 5881, 517

Umbrella review (other published meta-analyses)