Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

ASD (Autism spectrum disorder): Risk

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15000
R61410
Brennan, 2023 Probable Autism spectrum disorder (ASD) - The Modified Checklist for Autism in Toddlers-Revised (ages 16 to 30 months old) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.00 [0.20;5.80] -/-   -/- - -
ref
S480
R18074
El Marroun (Control unexposed, disease free), 2014 Pervasive developmental problems (Parent-reported subscale of the Child Behavior Checklist for ages 1.5–6 (above the 93rd percentile)) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: Yes Monotherapy: no or not specified 1.91 [1.13;3.47]
excluded (control group)
-/69   -/5,531 - 69
ref
S6591
R18078
El Marroun (Control unexposed, sick), 2014 Pervasive developmental problems (Parent-reported subscale of the Child Behavior Checklist for ages 1.5–6 (above the 93rd percentile)) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.33 [0.68;2.57] -/69   -/376 - 69
ref
Total 2 studies 1.28 [0.69;2.38] 0 69
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Brennan, 2023Brennan, 2023 1.00[0.20; 5.80]--13%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: moderate El Marroun (Control unexposed, sick), 2014El Marroun, 2014 1 1.33[0.68; 2.57]-6987%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.28[0.69; 2.38]-690.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.69; 2.38]-690%NABrennan, 2023 El Marroun (Control unexposed, sick), 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.19; 5.39]-- -NABrennan, 2023 1 unexposed, sickunexposed, sick 1.33[0.68; 2.59]-69 -NAEl Marroun (Control unexposed, sick), 2014 1 Tags Adjustment   - No  - No 1.00[0.19; 5.39]-- -NABrennan, 2023 1   - Yes  - Yes 1.33[0.68; 2.59]-69 -NAEl Marroun (Control unexposed, sick), 2014 1 Monotherapy   - no or not specified  - no or not specified 1.28[0.69; 2.38]-690%NABrennan, 2023 El Marroun (Control unexposed, sick), 2014 2 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.33[0.68; 2.59]-69 -NAEl Marroun (Control unexposed, sick), 2014 1 All studiesAll studies 1.28[0.69; 2.38]-690%NABrennan, 2023 El Marroun (Control unexposed, sick), 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 480

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.79[1.05; 3.05]-690%NABrennan, 2023 El Marroun (Control unexposed, disease free), 2014 2 unexposed, sick controlsunexposed, sick controls 1.33[0.68; 2.59]-69 -NAEl Marroun (Control unexposed, sick), 2014 10.510.01.0