Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Severe cognitive developmental delay (Mental retardation) (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8046
R24482		 Batton, 2013 High-risk range of neurodevelopmental delay with the Bayley Infant Neuro-developmental Screener (BINS) at 24 months during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: No Monotherapy: SSRI only 0.37 [0.09;1.53] C 4/19   8/19 12 19
ref
Total 1 studies 0.37 [0.09;1.53] 12 19
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Batton, 2013Batton, 2013 0.37[0.09; 1.53]12190%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.09; 1.53]1219 -NABatton, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.37[0.09; 1.53]1219 -NABatton, 2013 1 Tags Adjustment   - No  - No 0.37[0.09; 1.53]1219 -NABatton, 2013 1 Monotherapy   - SSRI only  - SSRI only 0.37[0.09; 1.53]1219 -NABatton, 2013 1 All studiesAll studies 0.37[0.09; 1.53]1219 -NABatton, 2013 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.37[0.09; 1.53]1219 -NABatton, 2013 10.510.01.0