Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14988
R61345		 Gover, 2023 Intraventricular hemorrhage throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 0.16 [0.02;1.51] C 1/21   5/21 6 21
ref
S5430
R21360		 Norby, 2016 Intracranial hemorrhage during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.90 [0.70;1.20] 52/17,736   1,897/718,533 1,949 17,736
ref
S8046
R24477		 Batton, 2013 Intraventricular hemorrhage during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: No Monotherapy: SSRI only 0.79 [0.21;3.03] C 6/19   7/19 13 19
ref
Total 3 studies 0.83 [0.52;1.32] 1,968 17,776
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gover, 2023Gover, 2023 0.16[0.02; 1.51]6214%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Norby, 2016Norby, 2016 0.90[0.70; 1.20]1,94917,73685%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Batton, 2013Batton, 2013 0.79[0.21; 3.03]131911%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 12% 0.83[0.52; 1.32]1,96817,7760.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.52; 1.32]1,96817,77612%NAGover, 2023 Norby, 2016 Batton, 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.83[0.52; 1.32]1,96817,77612%NAGover, 2023 Norby, 2016 Batton, 2013 3 Tags Adjustment   - No  - No 0.46[0.11; 2.03]194030%NAGover, 2023 Batton, 2013 2   - Yes  - Yes 0.90[0.69; 1.18]1,94917,736 -NANorby, 2016 1 MatchedMatched 0.16[0.02; 1.51]621 -NAGover, 2023 1 Monotherapy   - no or not specified  - no or not specified 0.55[0.12; 2.54]1,95517,75755%NAGover, 2023 Norby, 2016 2   - SSRI only  - SSRI only 0.79[0.21; 3.03]1319 -NABatton, 2013 1 All studiesAll studies 0.83[0.52; 1.32]1,96817,77612%NAGover, 2023 Norby, 2016 Batton, 2013 30.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.83[0.52; 1.32]1,96817,77612%NAGover, 2023 Norby, 2016 Batton, 2013 30.510.01.0