Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Feeding difficulty

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5430
R21361		 Norby, 2016 Feeding difficulties during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.00 [0.90;1.20] 227/17,736   6,777/718,533 7,004 17,736
ref
S5428
R20527		 Colvin, 2012 Feeding problems of newborn during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.17 [1.02;1.35] 217/3,297   4,881/86,110 5,098 3,297
ref
S5394
R20685		 Davis, 2007 Feeding problems in the newborn 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.26 [0.97;1.65] 52/874   3,444/75,219 3,496 874
ref
Total 3 studies 1.11 [0.98;1.27] 15,598 21,907
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Norby, 2016Norby, 2016 1.00[0.90; 1.20]7,00417,73640%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Colvin, 2012Colvin, 2012 1.17[1.02; 1.35]5,0983,29741%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Davis, 2007Davis, 2007 1.26[0.97; 1.65]3,49687418%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 42% 1.11[0.98; 1.27]15,59821,9070.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.98; 1.27]15,59821,90742%NANorby, 2016 Colvin, 2012 Davis, 2007 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.11[0.98; 1.27]15,59821,90742%NANorby, 2016 Colvin, 2012 Davis, 2007 3 Tags Adjustment   - No  - No 1.19[1.05; 1.35]8,5944,1710%NAColvin, 2012 Davis, 2007 2   - Yes  - Yes 1.00[0.87; 1.15]7,00417,736 -NANorby, 2016 1 Monotherapy   - no or not specified  - no or not specified 1.11[0.98; 1.27]15,59821,90742%NANorby, 2016 Colvin, 2012 Davis, 2007 3 All studiesAll studies 1.11[0.98; 1.27]15,59821,90742%NANorby, 2016 Colvin, 2012 Davis, 2007 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.98; 1.27]15,59821,90742%NANorby, 2016 Colvin, 2012 Davis, 2007 30.510.01.0