Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Child/Infant weight abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5368
R17710		 Grzeskowiak (Controls unexposed, disease free), 2013 Children overweight at 7 years of age during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes Monotherapy: SSRI only 1.39 [0.94;2.05]
excluded (control group) 		-/127   -/35,568 - 127
ref
S6459
R17713		 Grzeskowiak (Controls unexposed, sick), 2013 Children overweight at 7 years of age during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: SSRI only Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.12 [0.71;1.77] -/127   -/490 - 127
ref
S5369
R20052		 Grzeskowiak b (Controls unexposed, disease free), 2012 Childhood overweight at 4–5 years of age (male and female) during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: Yes Monotherapy: SSRI only 0.76 [0.45;1.30]
excluded (control group) 		-/71   -/6,285 - 71
ref
S6457
R20053		 Grzeskowiak b (Controls unexposed, sick), 2012 Childhood overweight at 4–5 years of age (males and females) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: Yes Monotherapy: SSRI only Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.83 [0.42;1.64] -/71   -/204 - 71
ref
Total 2 studies 1.02 [0.70;1.49] 0 198
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Grzeskowiak (Controls unexposed, sick), 2013Grzeskowiak, 2013 1 1.12[0.71; 1.77]-12769%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Grzeskowiak b (Controls unexposed, sick), 2012Grzeskowiak b, 2012 2 0.83[0.42; 1.64]-7131%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.02[0.70; 1.49]-1980.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 2 Tags Adjustment   - Yes  - Yes 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 2 Monotherapy   - SSRI only  - SSRI only 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 2 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 2 All studiesAll studies 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5369, 5368

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.59; 1.91]-19869%NAGrzeskowiak (Controls unexposed, disease free), 2013 Grzeskowiak b (Controls unexposed, disease free), 2012 2 unexposed, sick controlsunexposed, sick controls 1.02[0.70; 1.49]-1980%NAGrzeskowiak (Controls unexposed, sick), 2013 Grzeskowiak b (Controls unexposed, sick), 2012 20.510.01.0