Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Amniotic fluid problems (polyhydramnios and/or oligohydramnios)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7570
R22757		 Kivistö, 2016 Polyhydramnion or Oligohydramnion (amniotic fluid volume was assessed by trained nursing staff during the delivery) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: SSRI only 1.23 [0.94;1.61] C 67/358   3,852/24,402 3,919 358
ref
Total 1 studies 1.23 [0.94;1.61] 3,919 358
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kivistö, 2016Kivistö, 2016 1.23[0.94; 1.61]3,9193580%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 1 Tags Adjustment   - No  - No 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 1 Monotherapy   - SSRI only  - SSRI only 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 1 All studiesAll studies 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.94; 1.61]3,919358 -NAKivistö, 2016 10.510.01.0