Selective Serotonin Reuptake Inhibitor (SSRI) - Medication and Pregnancy KB

Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Neonatal tachypnea

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13112 R49962	Marks - Sertraline (Controls exposed to Bupropion), 2021	Transient tachypnea of the newborn	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.23 [0.84;1.80] ^C	172/1,653 35/406	207	1,653		ref
S10062 R36573	Bracero, 2016	Tachypnea	days before delivery	retrospective cohort	unexposed, sick	Adjustment: No Monotherapy: no or not specified	1.63 [0.08;34.23] ^C	0/6 4/85	4	6		ref
S5430 R21352	Norby, 2016	Transient tachypnea/other respiratory disease	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	1.70 [1.60;1.90]	819/17,736 15,860/718,533	16,679	17,736		ref
S5423 R19475	Levinson-Castiel, 2006	Tachypnea	3rd trimester	retrospective cohort	unexposed, disease free	Adjustment: No Matched Monotherapy: no or not specified	31.32 [1.81;542.66] ^C	12/60 0/60	12	60		ref
					Total	4 studies	1.59 [1.06;2.37]		16,902	19,455
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls exposed to Bupropion;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded