Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Childhood asthma

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10053
R36500		 Liu, 2015 Asthma in the offspring during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: SSRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.95 [0.88;1.03] 882/7,186   1,727/12,476 2,609 7,186
ref
Total 1 studies 0.95 [0.88;1.03] 2,609 7,186
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liu, 2015Liu, 2015 0.95[0.88; 1.03]2,6097,1860%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 1 Tags Adjustment   - Yes  - Yes 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 1 Monotherapy   - SSRI only  - SSRI only 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 1 All studiesAll studies 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.95[0.88; 1.03]2,6097,186 -NALiu, 2015 10.510.01.0