Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Low Apgar score (< 7) (NOS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7107
R20024		 Källén (Controls exposed to TCA), 2004 Low Apgar Score (NOS) late pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: SSRI only 0.83 [0.34;2.04] C
excluded (control group) 		11/500   9/343 20 500
ref
S485
R18114		 Källén (Controls unexposed, NOS), 2004 Low Apgar Score (NOS) late pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 2.28 [1.27;4.10] 11/500   4,972/530,795 4,983 500
ref
Total 1 studies 2.28 [1.27;4.10] 4,983 500
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén (Controls unexposed, NOS), 2004Källén, 2004 1 2.28[1.27; 4.10]4,9835000%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: NAROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 1 Tags Adjustment   - Yes  - Yes 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 1 Monotherapy   - SSRI only  - SSRI only 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 1 All studiesAll studies 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 7107

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.28[1.27; 4.10]4,983500 -NAKällén (Controls unexposed, NOS), 2004 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.83[0.34; 2.04]20500 -NAKällén (Controls exposed to TCA), 2004 10.510.01.0