Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Small for gestational age (length)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7570
R22786		 Kivistö, 2016 Length of the child <10th centile during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.18 [0.81;1.72] 35/-   1,847/- 1,882 -
ref
S10040
R36264		 Davidson, 2009 Birth lenght <10th percentile for age throughout pregnancy retrospective cohort unexposed, disease free Adjustment: No Matched Monotherapy: no or not specified 7.80 [0.38;161.88] C 3/21   0/20 3 21
ref
Total 2 studies 1.63 [0.41;6.52] 1,885 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kivistö, 2016Kivistö, 2016 1.18[0.81; 1.72]1,882-83%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Davidson, 2009Davidson, 2009 7.80[0.38; 161.88]32117%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 32% 1.63[0.41; 6.52]1,885210.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[0.41; 6.52]1,8852132%NAKivistö, 2016 Davidson, 2009 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.63[0.41; 6.52]1,8852132%NAKivistö, 2016 Davidson, 2009 2 Tags Adjustment   - No  - No 7.80[0.38; 161.88]321 -NADavidson, 2009 1   - Yes  - Yes 1.18[0.81; 1.72]1,882- -NAKivistö, 2016 1 MatchedMatched 7.80[0.38; 161.88]321 -NADavidson, 2009 1 Monotherapy   - no or not specified  - no or not specified 7.80[0.38; 161.88]321 -NADavidson, 2009 1   - SSRI only  - SSRI only 1.18[0.81; 1.72]1,882- -NAKivistö, 2016 1 All studiesAll studies 1.63[0.41; 6.52]1,8852132%NAKivistö, 2016 Davidson, 2009 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.63[0.41; 6.52]1,8852132%NAKivistö, 2016 Davidson, 2009 20.510.01.0