Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7570
R22758		 Kivistö, 2016 Placental abruption during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: SSRI only 0.39 [0.05;2.81] C 1/358   173/24,402 174 358
ref
S5405
R16044		 Wen, 2006 Placental abruption 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: no or not specified 1.56 [0.99;2.46]
excluded (exposition period) 		30/972   69/3,878 99 972
ref
Total 1 studies 0.39 [0.05;2.81] 174 358
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kivistö, 2016Kivistö, 2016 0.39[0.05; 2.81]1743580%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.39[0.05; 2.81]174358 -NAKivistö, 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.39[0.05; 2.81]174358 -NAKivistö, 2016 1 Tags Adjustment   - No  - No 0.39[0.05; 2.81]174358 -NAKivistö, 2016 1 Monotherapy   - SSRI only  - SSRI only 0.39[0.05; 2.81]174358 -NAKivistö, 2016 1 All studiesAll studies 0.39[0.05; 2.81]174358 -NAKivistö, 2016 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.39[0.05; 2.81]174358 -NAKivistö, 2016 10.510.01.0