Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5372
R18268		 Jordan, 2016 Polydactyly 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.90 [0.48;1.68] C
excluded (exposition period) 		10/12,962   434/506,155 444 12,962
ref
S495
R76921		 Källén, 2007 Poly- or syndactyly early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.09 [0.61;1.98] 14/6,555   2,042/873,876 2,056 6,555
ref
Total 1 studies 1.09 [0.61;1.96] 2,056 6,555
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén, 2007Källén, 2007 1.09[0.61; 1.98]2,0566,5550%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 1 Tags Adjustment   - Yes  - Yes 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 1 Monotherapy   - SSRI only  - SSRI only 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 1 All studiesAll studies 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.61; 1.96]2,0566,555 -NAKällén, 2007 10.510.01.0