Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Atresia or stenosis of other parts of small intestine

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5364
R16338		 Nishigori, 2017 Small intestine atresia 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 40.02 [5.23;306.03] 1/172   14/95,433 15 172
ref
S495
R76916		 Källén, 2007 Small gut atresia early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.63 [0.44;4.18] 4/6,555   332/873,876 336 6,555
ref
Total 2 studies 7.19 [0.31;164.13] 351 6,727
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nishigori, 2017Nishigori, 2017 40.02[5.23; 306.03]1517246%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Källén, 2007Källén, 2007 1.63[0.44; 4.18]3366,55554%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 86% 7.19[0.31; 164.13]3516,7270.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.19[0.31; 164.13]3516,72786%NANishigori, 2017 Källén, 2007 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.19[0.31; 164.13]3516,72786%NANishigori, 2017 Källén, 2007 2 Tags Adjustment   - No  - No 40.02[5.23; 306.01]15172 -NANishigori, 2017 1   - Yes  - Yes 1.63[0.53; 5.02]3366,555 -NAKällén, 2007 1 Monotherapy   - no or not specified  - no or not specified 40.02[5.23; 306.01]15172 -NANishigori, 2017 1   - SSRI only  - SSRI only 1.63[0.53; 5.02]3366,555 -NAKällén, 2007 1 All studiesAll studies 7.19[0.31; 164.13]3516,72786%NANishigori, 2017 Källén, 2007 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.19[0.31; 164.13]3516,72786%NANishigori, 2017 Källén, 2007 20.510.01.0