Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Hirschsprung's disease

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7450
R21997		 Granstrom, 2019 Hirschsprung disease 3 months (or more) before pregnancy or during pregnancy excluded nested case control unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.58 [0.57;4.39] C
excluded (exposition period) 		5/21   145/879 150 21
ref
S7452
R22008		 Nielsen, 2017 Hirschsprung’s disease 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.76 [1.07;2.92] 16/19,807   584/1,236,510 600 19,807
ref
S5372
R18259		 Jordan, 2016 Hirschsprung's defects 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.11 [0.77;5.77] C
excluded (exposition period) 		4/12,962   74/506,155 78 12,962
ref
Total 1 studies 1.76 [1.07;2.91] 600 19,807
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nielsen, 2017Nielsen, 2017 1.76[1.07; 2.92]60019,8070%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 1 Tags Adjustment   - Yes  - Yes 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 1 Monotherapy   - no or not specified  - no or not specified 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 1 All studiesAll studies 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.76[1.07; 2.91]60019,807 -NANielsen, 2017 10.510.01.0