Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Pulmonary valve stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22098		 Anderson, 2020 Pulmonary valve stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.86 [1.44;2.39] -/-   0/- - -
ref
S7348
R21423		 Wemakor, 2015 Pulmonary valve stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.30 [0.60;2.83] 7/106   765/17,749 772 106
ref
Total 2 studies 1.80 [1.41;2.29] 772 106
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.86[1.44; 2.39]--90%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.30[0.60; 2.83]77210610%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.80[1.41; 2.29]7721060.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - Yes  - Yes 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 2 Monotherapy   - SSRI only  - SSRI only 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.80[1.41; 2.29]7721060%NAAnderson, 2020 Wemakor, 2015 20.510.01.0