Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22094		 Anderson, 2020 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.14 [0.81;1.59] -/-   0/- - -
ref
S7348
R21427		 Wemakor, 2015 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.12 [0.41;3.07] 4/103   566/17,550 570 103
ref
S11325
R41721		 Louik, 2014 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.80 [1.20;2.90] 22/312   449/8,770 471 312
ref
Total 3 studies 1.35 [0.97;1.88] 1,041 415
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.14[0.81; 1.59]--53%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.12[0.41; 3.07]57010310%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2014Louik, 2014 1.80[1.20; 2.90]47131238%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 27% 1.35[0.97; 1.88]1,0414150.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.35[0.97; 1.88]1,04141527%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.35[0.97; 1.88]1,04141527%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Tags Adjustment   - Yes  - Yes 1.35[0.97; 1.88]1,04141527%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Monotherapy   - no or not specified  - no or not specified 1.80[1.16; 2.80]471312 -NALouik, 2014 1   - SSRI only  - SSRI only 1.14[0.83; 1.57]5701030%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.35[0.97; 1.88]1,04141527%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.35[0.97; 1.88]1,04141527%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 30.510.01.0