Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Encephalocele

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22112		 Anderson, 2020 Encephalocele 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 0.75 [0.28;2.05] -/-   0/- - -
ref
S5372
R18240		 Jordan, 2016 Encephalocele 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.19 [1.15;8.84] C
excluded (exposition period) 		4/12,962   49/506,155 53 12,962
ref
Total 1 studies 0.75 [0.28;2.03] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.75[0.28; 2.05]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.75[0.28; 2.03]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.75[0.28; 2.03]-- -NAAnderson, 2020 1 Tags Adjustment   - Yes  - Yes 0.75[0.28; 2.03]-- -NAAnderson, 2020 1 Monotherapy   - SSRI only  - SSRI only 0.75[0.28; 2.03]-- -NAAnderson, 2020 1 All studiesAll studies 0.75[0.28; 2.03]-- -NAAnderson, 2020 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.75[0.28; 2.03]-- -NAAnderson, 2020 10.510.01.0