Selective Serotonin Reuptake Inhibitor (SSRI) - Medication and Pregnancy KB

Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Hydrocephaly

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S7467 R22113	Anderson, 2020	Hydrocephaly	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SSRI only	0.99 [0.57;1.71]	-/- 0/-	-	-		ref
S5364 R16336	Nishigori, 2017	Hydrencephalus	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	16.09 [3.91;66.15]	2/172 70/95,433	72	172		ref
S5372 R18242	Jordan, 2016	Hydrocephaly	3 months or more before pregnancy or1st trimester excluded	retrospective cohort (registry)	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	0.80 [0.33;1.93] ^C excluded (exposition period)	5/12,962 245/506,155	250	12,962		ref
					Total	2 studies	3.69 [0.24;56.44]		72	172
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded