Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22137		 Anderson, 2020 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.28 [0.92;1.77] -/-   0/- - -
ref
S7485
R22405		 Given, 2017 Gastroschisis (excluding diabetes and anti-epileptic medication exposed) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.55 [1.44;4.49] 13/471   -/- - 471
ref
S516
R15362		 Furu (Controls unexposed, NOS), 2015 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.65 [0.87;3.15] 11/36,772   413/2,266,875 424 36,772
ref
Total 3 studies 1.67 [1.09;2.55] 424 37,243
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.28[0.92; 1.77]--45%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Given, 2017Given, 2017 2.55[1.44; 4.49]-47129%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Furu (Controls unexposed, NOS), 2015Furu, 2015 1 1.65[0.87; 3.15]42436,77225%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 53% 1.67[1.09; 2.55]42437,2430.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.65[0.87; 3.14]42436,772 -NAFuru (Controls unexposed, NOS), 2015 1 case control studiescase control studies 1.73[0.89; 3.39]-47176%NAAnderson, 2020 Given, 2017 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.67[1.09; 2.55]42437,24353%NAAnderson, 2020 Given, 2017 Furu (Controls unexposed, NOS), 2015 3 Tags Adjustment   - Yes  - Yes 1.67[1.09; 2.55]42437,24353%NAAnderson, 2020 Given, 2017 Furu (Controls unexposed, NOS), 2015 3 Monotherapy   - no or not specified  - no or not specified 2.55[1.44; 4.50]-471 -NAGiven, 2017 1   - SSRI only  - SSRI only 1.35[1.01; 1.81]42436,7720%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 2 All studiesAll studies 1.67[1.09; 2.55]42437,24353%NAAnderson, 2020 Given, 2017 Furu (Controls unexposed, NOS), 2015 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.67[1.09; 2.55]42437,24353%NAAnderson, 2020 Given, 2017 Furu (Controls unexposed, NOS), 2015 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Gao - SSRI (Gastroschisis)Gao - SSRI (Gastroschisis) 1.89[1.19; 3.00]-U,GPunexposed (general population or NOS)T11st trimesterstudies TTT2 metaPregmetaPreg 1.67[1.09; 2.55]53%37,243----Anderson, 2020 Given, 2017 Furu (Controls unexposed, NOS), 2015 30.510.01.0