Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22111		 Anderson, 2020 Spina bifida 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 0.91 [0.62;1.32] -/-   0/- - -
ref
S5372
R18241		 Jordan, 2016 Spina Bifida 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.19 [0.56;2.52] C
excluded (exposition period) 		7/12,962   230/506,155 237 12,962
ref
S5394
R20636		 Davis, 2007 Spina bifida 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.21 [0.30;16.00] 1/805   28/49,031 29 805
ref
Total 2 studies 0.94 [0.65;1.36] 29 805
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.91[0.62; 1.32]--97%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 2.21[0.30; 16.00]298053%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.94[0.65; 1.36]298050.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.21[0.30; 16.14]29805 -NADavis, 2007 1 case control studiescase control studies 0.91[0.62; 1.33]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.65; 1.36]298050%NAAnderson, 2020 Davis, 2007 2 Tags Adjustment   - No  - No 2.21[0.30; 16.14]29805 -NADavis, 2007 1   - Yes  - Yes 0.91[0.62; 1.33]-- -NAAnderson, 2020 1 Monotherapy   - no or not specified  - no or not specified 2.21[0.30; 16.14]29805 -NADavis, 2007 1   - SSRI only  - SSRI only 0.91[0.62; 1.33]-- -NAAnderson, 2020 1 All studiesAll studies 0.94[0.65; 1.36]298050%NAAnderson, 2020 Davis, 2007 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.65; 1.36]298050%NAAnderson, 2020 Davis, 2007 20.510.01.0