Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22124		 Anderson, 2020 Esophageal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.47 [1.02;2.11] -/-   0/- - -
ref
S5364
R16337		 Nishigori, 2017 Esophageal atresia 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 25.47 [3.41;189.98] 1/172   22/95,433 23 172
ref
S495
R76914		 Källén, 2007 Esophageal atresia early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.25 [0.31;4.98] 3/6,555   417/873,876 420 6,555
ref
Total 3 studies 2.70 [0.69;10.53] 443 6,727
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.47[1.02; 2.11]--45%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Nishigori, 2017Nishigori, 2017 25.47[3.41; 189.98]2317223%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Källén, 2007Källén, 2007 1.25[0.31; 4.98]4206,55531%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 74% 2.70[0.69; 10.53]4436,7270.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.15[0.27; 98.26]4436,72783%NANishigori, 2017 Källén, 2007 2 case control studiescase control studies 1.47[1.02; 2.11]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.70[0.69; 10.53]4436,72774%NAAnderson, 2020 Nishigori, 2017 Källén, 2007 3 Tags Adjustment   - No  - No 25.47[3.41; 190.00]23172 -NANishigori, 2017 1   - Yes  - Yes 1.45[1.02; 2.07]4206,5550%NAAnderson, 2020 Källén, 2007 2 Monotherapy   - no or not specified  - no or not specified 25.47[3.41; 190.00]23172 -NANishigori, 2017 1   - SSRI only  - SSRI only 1.45[1.02; 2.07]4206,5550%NAAnderson, 2020 Källén, 2007 2 All studiesAll studies 2.70[0.69; 10.53]4436,72774%NAAnderson, 2020 Nishigori, 2017 Källén, 2007 30.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.70[0.69; 10.53]4436,72774%NAAnderson, 2020 Nishigori, 2017 Källén, 2007 30.510.01.0