Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Diaphragmatic hernia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22135		 Anderson, 2020 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.22 [0.83;1.79] -/-   0/- - -
ref
S5372
R18260		 Jordan, 2016 Diaphragmatic hernia 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.44 [1.19;4.99] C
excluded (exposition period) 		8/12,962   128/506,155 136 12,962
ref
S495
R76919		 Källén, 2007 Diaphragmatic hernia early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.27 [0.15;4.57] 2/6,555   246/873,876 248 6,555
ref
S5424
R16111		 Louik, 2007 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.80 [0.70;4.20] 6/166   186/5,886 192 166
ref
Total 3 studies 1.29 [0.92;1.83] 440 6,721
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.22[0.83; 1.79]--81%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Källén, 2007Källén, 2007 1.27[0.15; 4.57]2486,5554%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Louik, 2007Louik, 2007 1.80[0.70; 4.20]19216615%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.29[0.92; 1.83]4406,7210.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[0.23; 7.01]2486,555 -NAKällén, 2007 1 case control studiescase control studies 1.30[0.91; 1.84]1921660%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.29[0.92; 1.83]4406,7210%NAAnderson, 2020 Källén, 2007 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.29[0.92; 1.83]4406,7210%NAAnderson, 2020 Källén, 2007 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 1.80[0.73; 4.41]192166 -NALouik, 2007 1   - SSRI only  - SSRI only 1.22[0.84; 1.78]2486,5550%NAAnderson, 2020 Källén, 2007 2 All studiesAll studies 1.29[0.92; 1.83]4406,7210%NAAnderson, 2020 Källén, 2007 Louik, 2007 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.29[0.92; 1.83]4406,7210%NAAnderson, 2020 Källén, 2007 Louik, 2007 30.510.01.0