Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Patent ductus arterious

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5372
R18255		 Jordan, 2016 Patent ductus arterious as only CHD in term infants 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.73 [0.37;1.48] C
excluded (exposition period) 		8/12,962   425/506,155 433 12,962
ref
S5430
R21362		 Norby, 2016 Treated patent ductus arteriosus during pregnancy (anytime or not specified) excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.30 [1.00;1.80]
excluded (exposition period) 		50/17,736   1,362/718,533 1,412 17,736
ref
S493
R15253		 Colvin, 2011 Patent ductus arteriosus adjusted for gestational age 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.07 [1.65;5.73] 11/2,701   111/94,561 122 2,701
ref
Total 1 studies 3.07 [1.65;5.72] 122 2,701
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 3.07[1.65; 5.73]1222,7010%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 1 Tags Adjustment   - No  - No 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 1 Monotherapy   - no or not specified  - no or not specified 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 1 All studiesAll studies 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.07[1.65; 5.72]1222,701 -NAColvin, 2011 10.510.01.0