Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22088		 Anderson, 2020 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.42 [0.85;2.38] -/-   0/- - -
ref
S516
R15353		 Furu (Controls unexposed, NOS), 2015 Atrioventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.22 [0.77;1.91] 22/36,772   1,073/2,266,875 1,095 36,772
ref
S7348
R21442		 Wemakor, 2015 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 2.08 [0.76;5.73] 4/103   286/17,270 290 103
ref
S11325
R41726		 Louik, 2014 Atrioventricular canal defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.30 [0.80;2.00] 19/309   502/8,823 521 309
ref
S5386
R15152		 Margulis, 2013 Atrioventricular septal defects (first year of life) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Matched Monotherapy: SSRI only 0.98 [0.04;24.16] C 0/3,046   1/8,991 1 3,046
ref
Total 5 studies 1.34 [1.03;1.75] 1,907 40,230
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.42[0.85; 2.38]--26%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Furu (Controls unexposed, NOS), 2015Furu, 2015 1 1.22[0.77; 1.91]1,09536,77234%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 2.08[0.76; 5.73]2901037%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2014Louik, 2014 1.30[0.80; 2.00]52130933%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Margulis, 2013Margulis, 2013 0.98[0.04; 24.16]13,0461%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (5 studies) I2 = 0% 1.34[1.03; 1.75]1,90740,2300.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.77; 1.90]1,09639,8180%NAFuru (Controls unexposed, NOS), 2015 Margulis, 2013 2 case control studiescase control studies 1.41[1.02; 1.95]8114120%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.34[1.03; 1.75]1,90740,2300%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 Louik, 2014 Margulis, 2013 5 Tags Adjustment   - No  - No 0.98[0.04; 24.16]13,046 -NAMargulis, 2013 1   - Yes  - Yes 1.34[1.03; 1.75]1,90637,1840%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 Louik, 2014 4 MatchedMatched 0.98[0.04; 24.16]13,046 -NAMargulis, 2013 1 Monotherapy   - no or not specified  - no or not specified 1.30[0.82; 2.06]521309 -NALouik, 2014 1   - SSRI only  - SSRI only 1.36[0.99; 1.88]1,38639,9210%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 Margulis, 2013 4 All studiesAll studies 1.34[1.03; 1.75]1,90740,2300%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 Louik, 2014 Margulis, 2013 50.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.84.11.9600.000Anderson, 2020Furu (Controls unexposed, NOS), 2015Wemakor, 2015Louik, 2014Margulis, 2013

Asymetry test p-value = 0.5823 (by Egger's regression)

slope=0.2033 (0.1647); intercept=0.3375 (0.5490); t=0.6146; p=0.5823

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.34[1.03; 1.75]1,90740,2300%NAAnderson, 2020 Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 Louik, 2014 Margulis, 2013 50.510.01.0