Venlafaxine updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11775
R43320		 Richardson, 2019 Intrauterine fetal death/stillbirth (after 24 weeks) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.36 [0.25;5.11] 3/214   12/1,162 15 214
ref
S11777
R43337		 Te Winkel, 2016 Stillbirths during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.65 [0.39;6.94] C 5/732   3/724 8 732
ref
Total 2 studies 1.51 [0.53;4.28] 23 946
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Richardson, 2019Richardson, 2019 1.36[0.25; 5.11]1521447%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Te Winkel, 2016Te Winkel, 2016 1.65[0.39; 6.94]873253%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.51[0.53; 4.28]239460.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 2 Tags Adjustment   - No  - No 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 2 MatchedMatched 1.36[0.30; 6.21]15214 -NARichardson, 2019 1 Monotherapy   - no or not specified  - no or not specified 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 2 All studiesAll studies 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.51[0.53; 4.28]239460%NARichardson, 2019 Te Winkel, 2016 20.510.01.0