Venlafaxine updated on 07-01-2025

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11780
R53840		 Nulman (Controls unexposed, disease free), 2012 Full-scale IQ (The Wechsler Preschool and Primary Scale of Intelligence– Third Edition) at 3-6 years during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No extrapolated (cont. endpoint) Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.72 [1.42;5.22]
excluded (control group) 		-/62   -/62 - 62
ref
S11781
R53841		 Nulman (Controls unexposed, sick), 2012 Full-scale IQ (The Wechsler Preschool and Primary Scale of Intelligence– Third Edition) at 3-6 years during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No extrapolated (cont. endpoint) Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.47 [0.76;2.86] -/62   -/54 - 62
ref
Total 1 studies 1.47 [0.76;2.85] 0 62
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nulman (Controls unexposed, sick), 2012Nulman, 2012 1 1.47[0.76; 2.86]-620%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: lowROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 1 All studiesAll studies 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11780

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.72[1.42; 5.22]-62 -NANulman (Controls unexposed, disease free), 2012 1 unexposed, sick controlsunexposed, sick controls 1.47[0.76; 2.85]-62 -NANulman (Controls unexposed, sick), 2012 10.510.01.0