Venlafaxine - Medication and Pregnancy KB

Venlafaxine updated on 07-01-2025

Low Apgar score (< 7) (at 5 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18311 R77112	Martin, 2024	Low Apgar score at 5 min (<7)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	2.04 [1.76;2.37]	209/5,769 30,996/2,078,011	31,205	5,769		ref
S13135 R50110	Marks (Controls exposed to Bupropion), 2021	5 Min APGAR <7	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.27 [0.73;2.23] ^C	20/132 50/406	70	132		ref
S13353 R51475	Calderon-Margalit, 2009	APGAR Score at 5 minute <7	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	11.60 [1.85;72.60]	-/9 -/2,493	-	9		ref
					Total	3 studies	1.99 [1.10;3.61]		31,275	5,910
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls exposed to Bupropion;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded