Paroxetine updated on 07-01-2025

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18437
R78172		 Lee (Controls exposed to TCAs), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.38 [0.02;6.46] C
excluded (control group) 		0/77   10/613 10 77
ref
S18419
R77930		 Lee (Controls unexposed, general pop), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.30 [0.02;4.91] C 0/77   9,744/463,440 9,744 77
ref
S7698
R22845		 Kivistö, 2016 Large for gestational age (birthweight >10th centile) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.14 [0.34;3.87] -/32   2,191/24,402 - 32
ref
Total 2 studies 0.92 [0.30;2.81] 9,744 109
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 0.30[0.02; 4.91]9,7447716%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Kivistö, 2016Kivistö, 2016 1.14[0.34; 3.87]-3284%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.92[0.30; 2.81]9,7441090.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.30; 2.81]9,7441090%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.92[0.30; 2.81]9,7441090%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Tags Adjustment   - No  - No 0.30[0.02; 4.91]9,74477 -NALee (Controls unexposed, general pop), 2025 1   - Yes  - Yes 1.14[0.34; 3.85]-32 -NAKivistö, 2016 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.92[0.30; 2.81]9,7441090%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 All studiesAll studies 0.92[0.30; 2.81]9,7441090%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18437

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.92[0.30; 2.81]11,9261090%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.38[0.02; 6.46]1077 -NALee (Controls exposed to TCAs), 2025 10.510.01.0