Paroxetine updated on 07-01-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7521
R22545		 Ozturk, 2016 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.11 [0.63;15.25] C 2/14   14/275 16 14
ref
S5957
R15291		 Diav-Citrin, 2008 Elective termination of pregnancy (ETOP) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.65 [0.98;2.79] C 22/463   43/1,467 65 463
ref
S6250
R16625		 Vial, 2006 Voluntary abortion 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 3.10 [1.90;5.40] 61/683   20/683 81 683
ref
Total 3 studies 2.32 [1.45;3.74] 162 1,160
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 3.11[0.63; 15.25]16148%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 1.65[0.98; 2.79]6546346%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Vial, 2006Vial, 2006 3.10[1.90; 5.40]8168346%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: unclear Total (3 studies) I2 = 31% 2.32[1.45; 3.74]1621,1600.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 3 Tags Adjustment   - No  - No 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 3 MatchedMatched 3.10[1.84; 5.23]81683 -NAVial, 2006 1 Monotherapy   - no or not specified  - no or not specified 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 3 All studiesAll studies 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.32[1.45; 3.74]1621,16031%NAOzturk, 2016 Diav-Citrin, 2008 Vial, 2006 30.510.01.0