Paroxetine updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7926
R23990		 Stephansson, 2013 Stillbirth (after 22 weeks of gestation) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.84 [1.20;2.83] C
excluded (exposition period) 		21/3,097   5,919/1,604,649 5,940 3,097
ref
S7180
R20237		 Colvin, 2011 Stillbirths during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.90 [0.34;2.42] -/685   612/94,561 - 685
ref
S5957
R15292		 Diav-Citrin, 2008 Stillbirth during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.59 [0.48;5.30] C 4/463   8/1,467 12 463
ref
Total 2 studies 1.13 [0.53;2.42] 12 1,148
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 0.90[0.34; 2.42]-68560%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 1.59[0.48; 5.30]1246340%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.13[0.53; 2.42]121,1480.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.13[0.53; 2.42]121,1480%NAColvin, 2011 Diav-Citrin, 2008 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.13[0.53; 2.42]121,1480%NAColvin, 2011 Diav-Citrin, 2008 2 Tags Adjustment   - No  - No 1.13[0.53; 2.42]121,1480%NAColvin, 2011 Diav-Citrin, 2008 2 Monotherapy   - no or not specified  - no or not specified 1.59[0.48; 5.30]12463 -NADiav-Citrin, 2008 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.90[0.34; 2.40]-685 -NAColvin, 2011 1 All studiesAll studies 1.13[0.53; 2.42]121,1480%NAColvin, 2011 Diav-Citrin, 2008 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[0.53; 2.42]6151,1480%NAColvin, 2011 Diav-Citrin, 2008 20.510.01.0