Paroxetine updated on 07-01-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7180
R20250		 Colvin, 2011 Terminations of Pregnancy (both spontaneous abortions and elective) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.33 [0.80;1.57] 194/763   24,313/119,840 24,507 763
ref
S5957
R25445		 Diav-Citrin, 2008 Intrauterine death (ETOP, Miscarriage, stillbirth, ectopic) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.52 [1.12;2.07] C 68/463   149/1,467 217 463
ref
Total 2 studies 1.43 [1.14;1.80] 24,724 1,226
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 1.33[0.80; 1.57]24,50776346%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 1.52[1.12; 2.07]21746354%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.43[1.14; 1.80]24,7241,2260.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[1.14; 1.80]24,7241,2260%NAColvin, 2011 Diav-Citrin, 2008 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.43[1.14; 1.80]24,7241,2260%NAColvin, 2011 Diav-Citrin, 2008 2 Tags Adjustment   - No  - No 1.43[1.14; 1.80]24,7241,2260%NAColvin, 2011 Diav-Citrin, 2008 2 Monotherapy   - no or not specified  - no or not specified 1.52[1.12; 2.07]217463 -NADiav-Citrin, 2008 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.33[0.95; 1.86]24,507763 -NAColvin, 2011 1 All studiesAll studies 1.43[1.14; 1.80]24,7241,2260%NAColvin, 2011 Diav-Citrin, 2008 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[1.14; 1.80]24,7241,2260%NAColvin, 2011 Diav-Citrin, 2008 20.510.01.0