Paroxetine updated on 07-01-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7470
R22266		 Anderson, 2020 Any oral cleft 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.00 [0.58;1.73] -/-   0/- - -
ref
S8216
R25605		 Jordan, 2016 Oro‐facial clefts 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.55 [0.08;3.91] C
excluded (exposition period) 		1/1,069   861/506,155 862 1,069
ref
S5886
R14750		 Ban (Controls unexposed, disease free), 2014 Orofacialcleft 1st trimester retrospective cohort (claims database) unexposed, disease free Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.31 [0.02;4.95] C 0/1,200   438/325,294 438 1,200
ref
S7228
R20761		 Davis, 2007 Cleft palate and cleft lip 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.26 [0.44;24.28] 1/182   92/49,654 93 182
ref
Total 3 studies 1.04 [0.62;1.75] 531 1,382
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.00[0.58; 1.73]--90%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Ban (Controls unexposed, disease free), 2014Ban, 2014 1 0.31[0.02; 4.95]4381,2004%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 3.26[0.44; 24.28]931827%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.04[0.62; 1.75]5311,3820.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.23[0.13; 11.96]5311,38245%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2 case control studiescase control studies 1.00[0.58; 1.73]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.62; 1.75]5311,3820%NAAnderson, 2020 Ban (Controls unexposed, disease free), 2014 Davis, 2007 3 Tags Adjustment   - No  - No 1.23[0.13; 11.96]5311,38245%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2   - Yes  - Yes 1.00[0.58; 1.73]-- -NAAnderson, 2020 1 Monotherapy   - no or not specified  - no or not specified 3.26[0.44; 24.22]93182 -NADavis, 2007 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.00[0.58; 1.73]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.31[0.02; 4.95]4381,200 -NABan (Controls unexposed, disease free), 2014 1 All studiesAll studies 1.04[0.62; 1.75]5311,3820%NAAnderson, 2020 Ban (Controls unexposed, disease free), 2014 Davis, 2007 30.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.62; 1.75]5311,3820%NAAnderson, 2020 Ban (Controls unexposed, disease free), 2014 Davis, 2007 30.510.01.0