Paroxetine updated on 07-01-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7434
R21892		 Bérard, 2017 Respiratory system malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.95 [0.41;2.21] -/1,132   -/14,847 - 1,132
ref
S7350
R21501		 Wemakor, 2015 Respiratory system anomalies 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.32 [0.02;5.18] C 0/27   983/18,039 983 27
ref
S5886
R14756		 Ban (Controls unexposed, disease free), 2014 Respiratory system malformations 1st trimester retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.25 [0.18;8.96] -/1,200   205/325,294 - 1,200
ref
S6017
R15562		 Jimenez-Solem (Controls unexposed, NOS), 2012 Malformations of the respiratory system 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.52 [0.21;10.80] 1/568   -/843,797 - 568
ref
S7180
R20243		 Colvin, 2011 Respiratory system defects 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 3.95 [0.97;16.08] -/572   84/94,561 - 572
ref
S6243
R16508		 Malm, 2011 Respiratory tract 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.67 [0.09;4.78] -/968   -/628,607 - 968
ref
S7228
R20760		 Davis, 2007 Congenital anomalies of respiratory system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.53 [0.03;8.50] C 0/182   257/49,654 257 182
ref
Total 7 studies 1.17 [0.65;2.09] 1,240 4,649
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2017Bérard, 2017 0.95[0.41; 2.21]-1,13248%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 0.32[0.02; 5.18]983274%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ban (Controls unexposed, disease free), 2014Ban, 2014 1 1.25[0.18; 8.96]-1,2009%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Jimenez-Solem (Controls unexposed, NOS), 2012Jimenez-Solem, 2012 2 1.52[0.21; 10.80]-5689%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical Colvin, 2011Colvin, 2011 3.95[0.97; 16.08]-57217%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 0.67[0.09; 4.78]-9689%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 0.53[0.03; 8.50]2571824%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (7 studies) I2 = 0% 1.17[0.65; 2.09]1,2404,6490.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free; 2: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.24[0.68; 2.25]2574,6220%NABérard, 2017 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Colvin, 2011 Malm, 2011 Davis, 2007 6 case control studiescase control studies 0.32[0.02; 5.18]98327 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.41[0.63; 3.17]1,2403,5170%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Colvin, 2011 Malm, 2011 Davis, 2007 6 unexposed, sickunexposed, sick 0.95[0.41; 2.21]-1,132 -NABérard, 2017 1 Tags Adjustment   - No  - No 1.28[0.23; 6.94]1,24078142%NAWemakor, 2015 Colvin, 2011 Davis, 2007 3   - Yes  - Yes 1.00[0.51; 1.96]-3,8680%NABérard, 2017 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Malm, 2011 4 Monotherapy   - no or not specified  - no or not specified 0.62[0.12; 3.11]2571,1500%NAMalm, 2011 Davis, 2007 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.87[0.39; 1.94]9831,1590%NABérard, 2017 Wemakor, 2015 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.32[0.86; 6.22]-2,3400%NABan (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Colvin, 2011 3 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.95[0.41; 2.21]-1,132 -NABérard, 2017 1 All studiesAll studies 1.17[0.65; 2.09]1,2404,6490%NABérard, 2017 Wemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Colvin, 2011 Malm, 2011 Davis, 2007 70.110.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.43.51.7130.000Bérard, 2017Wemakor, 2015Ban (Controls unexposed, disease free), 2014Jimenez-Solem (Controls unexposed, NOS), 2012Colvin, 2011Malm, 2011Davis, 2007

Asymetry test p-value = 0.6608 (by Egger's regression)

slope=0.4456 (0.6820); intercept=-0.4042 (0.8673); t=0.4661; p=0.6608

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.41[0.63; 3.17]1,5113,5170%NAWemakor, 2015 Ban (Controls unexposed, disease free), 2014 Jimenez-Solem (Controls unexposed, NOS), 2012 Colvin, 2011 Malm, 2011 Davis, 2007 6 unexposed, sick controlsunexposed, sick controls 0.95[0.41; 2.21]-1,132 -NABérard, 2017 10.510.01.0