Paroxetine updated on 07-01-2025

Cognitive developmental disorders/delay (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8148
R53800		 Van der Veere, 2020 Cognition (Bayley Scales of Infant and Toddler Development (BSID)) - At 2.5 years during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) Monotherapy: SSRI only 3.40 [1.37;8.42] -/27   -/41 - 27
ref
Total 1 studies 3.40 [1.37;8.43] 0 27
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Veere, 2020Van der Veere, 2020 3.40[1.37; 8.42]-270%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: lowROB reporting: low0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 1 Tags Adjustment   - No  - No 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 1 Monotherapy   - SSRI only  - SSRI only 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 1 All studiesAll studies 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.40[1.37; 8.43]-27 -NAVan der Veere, 2020 10.510.01.0