Paroxetine updated on 07-01-2025

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7350
R21478		 Wemakor, 2015 Severe congenital heart defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.08 [0.44;2.63] 6/33   2,929/19,985 2,935 33
ref
Total 1 studies 1.08 [0.44;2.64] 2,935 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wemakor, 2015Wemakor, 2015 1.08[0.44; 2.63]2,935330%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 1 Tags Adjustment   - Yes  - Yes 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 1 All studiesAll studies 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.44; 2.64]2,93533 -NAWemakor, 2015 10.510.01.0