Paroxetine updated on 07-01-2025

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8216
R25611		 Jordan, 2016 Omphalocele 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.56 [0.16;41.27] C
excluded (exposition period) 		0/1,069   92/506,155 92 1,069
ref
S6243
R16541		 Malm, 2011 Omphalocele 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.83 [0.25;13.25] -/968   -/628,607 - 968
ref
S6160
R16170		 Louik, 2007 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.76 [0.05;12.42] C 0/30   127/5,957 127 30
ref
Total 2 studies 1.36 [0.27;6.87] 127 998
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Malm, 2011Malm, 2011 1.83[0.25; 13.25]-96867%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 0.76[0.05; 12.42]1273033%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.36[0.27; 6.87]1279980.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.83[0.25; 13.32]-968 -NAMalm, 2011 1 case control studiescase control studies 0.76[0.05; 12.42]12730 -NALouik, 2007 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.36[0.27; 6.87]1279980%NAMalm, 2011 Louik, 2007 2 Tags Adjustment   - No  - No 0.76[0.05; 12.42]12730 -NALouik, 2007 1   - Yes  - Yes 1.83[0.25; 13.32]-968 -NAMalm, 2011 1 Monotherapy   - no or not specified  - no or not specified 1.83[0.25; 13.32]-968 -NAMalm, 2011 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.76[0.05; 12.42]12730 -NALouik, 2007 1 All studiesAll studies 1.36[0.27; 6.87]1279980%NAMalm, 2011 Louik, 2007 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.36[0.27; 6.87]1279980%NAMalm, 2011 Louik, 2007 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Omphalocele)Reefhuis (Omphalocele) 3.50[1.30; 8.00]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.36[0.27; 6.87]0%998----Malm, 2011 Louik, 2007 20.510.01.0