Paroxetine updated on 07-01-2025

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7180
R20251		 Colvin, 2011 Ectopic pregnancy 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.68 [0.58;1.51] 6/763   1,483/119,840 1,489 763
ref
S5957
R15293		 Diav-Citrin, 2008 Ectopic pregnancy during pregnancy (anytime or not specified) excluded prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.06 [0.04;25.97] C
excluded (exposition period) 		0/463   1/1,467 1 463
ref
Total 1 studies 0.68 [0.42;1.10] 1,489 763
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 0.68[0.58; 1.51]1,4897630%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 1 Tags Adjustment   - No  - No 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 1 All studiesAll studies 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.68[0.42; 1.10]1,489763 -NAColvin, 2011 10.510.01.0