Paroxetine updated on 07-01-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18437
R78177		 Lee (Controls exposed to TCAs), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 8.01 [0.16;406.45] C
excluded (control group) 		0/77   0/613 0 77
ref
S18419
R77935		 Lee (Controls unexposed, general pop), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 4.82 [0.30;77.86] C 0/77   627/463,440 627 77
ref
S7926
R23991		 Stephansson, 2013 Neonatal death (death within 0-27 days among live born infants) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.74 [0.31;1.77] C
excluded (exposition period) 		5/3,076   3,535/1,604,649 3,540 3,076
ref
Total 1 studies 4.82 [0.30;77.86] 627 77
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 4.82[0.30; 77.86]627770%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 1 Tags Adjustment   - No  - No 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18437

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.82[0.30; 77.86]62777 -NALee (Controls unexposed, general pop), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 8.01[0.16; 406.45]-77 -NALee (Controls exposed to TCAs), 2025 10.510.01.0