Fluoxetine updated on 07-01-2025

Small for gestational age (weight)

id	Study   Auto Lee (Controls exposed to TCAs), 2025Lee (Controls unexposed, general pop), 2025Martin, 2024Kivistö, 2016Chambers, 1996	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18436 R78150	Lee (Controls exposed to TCAs), 2025	Small for gestational age (birth weight <2 standard deviations below the mean for gestational age)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	0.85 [0.41;1.75] C excluded (control group)	15/719   15/613	30	719		ref
S18415 R77845	Lee (Controls unexposed, general pop), 2025	Small for gestational age (birth weight <2 standard deviations below the mean for gestational age)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.07 [0.63;1.81]	15/719   6,986/463,440	7,001	719		ref
S18218 R76439	Martin, 2024	Small for gestational age (SGA, defined as those with a birth weight in the lowest 10 percentiles for gestational age (<10th percentile)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.17 [1.10;1.24]	1,322/10,581   229,066/2,408,707	230,388	10,581		ref
S7693 R22804	Kivistö, 2016	Small for gestational age ( birthweight < 10th centile)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.13 [0.44;2.92]	-/51   2,336/24,402	-	51		ref
S15005 R61441	Chambers, 1996	Birth weight (<10th percentile) in full-term infants	late pregnancy	prospective cohort	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	3.74 [1.26;11.12] C	7/61   7/209	14	61		ref
					Total	4 studies	1.24 [0.92;1.66]		237,403	11,412
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 18436

Umbrella review (other published meta-analyses)