Fluoxetine updated on 07-01-2025

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6952
R19653		 Pastuszak (Controls unexposed, NOS), 1993 Birth weight > 4000g 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.74 [0.71;4.23] C 15/84   9/81 24 84
ref
Total 1 studies 1.74 [0.71;4.23] 24 84
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pastuszak (Controls unexposed, NOS), 1993Pastuszak, 1993 1 1.74[0.71; 4.23]24840%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 1 Tags Adjustment   - No  - No 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 1 MatchedMatched 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 1 All studiesAll studies 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.74[0.71; 4.23]2484 -NAPastuszak (Controls unexposed, NOS), 1993 10.510.01.0