Fluoxetine updated on 07-01-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18436
R78149		 Lee (Controls exposed to TCAs), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.84 [0.59;1.19] C
excluded (control group) 		68/719   68/613 136 719
ref
S18415
R77844		 Lee (Controls unexposed, general pop), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.00 [0.77;1.29] 68/719   31,347/463,440 31,415 719
ref
S7693
R22803		 Kivistö, 2016 Low birth weight (<2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.53 [0.12;2.40] -/51   1,573/24,402 - 51
ref
S7194
R20415		 Colvin, 2011 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.53 [1.10;2.14] 39/371   6,744/94,561 6,783 371
ref
Total 3 studies 1.16 [0.78;1.72] 38,198 1,141
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.00[0.77; 1.29]31,41571950%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Kivistö, 2016Kivistö, 2016 0.53[0.12; 2.40]-516%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Colvin, 2011Colvin, 2011 1.53[1.10; 2.14]6,78337144%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 60% 1.16[0.78; 1.72]38,1981,1410.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.16[0.78; 1.72]38,1981,14160%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.16[0.78; 1.72]38,1981,14160%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 Tags Adjustment   - No  - No 1.53[1.10; 2.13]6,783371 -NAColvin, 2011 1   - Yes  - Yes 0.98[0.76; 1.27]31,4157700%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.98[0.76; 1.27]31,4157700%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.53[1.10; 2.13]6,783371 -NAColvin, 2011 1 All studiesAll studies 1.16[0.78; 1.72]38,1981,14160%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18436

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.16[0.78; 1.72]39,7621,14160%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.84[0.59; 1.19]136719 -NALee (Controls exposed to TCAs), 2025 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 1.00[0.50; 2.00]-U,GPunexposed (general population or NOS)Anyduring pregnancy (anytime or not specified)studies TTT8 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 0.80[0.40; 1.80]-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT8 Xing (Low birth weight)Xing (Low birth weight) 1.18[0.48; 2.89]45%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.16[0.78; 1.72]60%1,141----Lee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.510.01.0