Fluoxetine updated on 07-01-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7525
R22561		 Ozturk, 2016 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.95 [0.05;17.06] C 0/10   14/275 14 10
ref
S6733
R19030		 Diav-Citrin, 2008 Elective termination of pregnancy (ETOP) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.80 [1.71;4.60] C 27/346   43/1,467 70 346
ref
S6202
R16365		 Pastuszak (Controls exposed to TCA), 1993 Elective abortions 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.22 [0.35;4.18] C
excluded (control group) 		6/74   5/74 11 74
ref
S6952
R19657		 Pastuszak (Controls unexposed, NOS), 1993 Elective abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.41 [0.55;3.63] C 11/128   8/128 19 128
ref
Total 3 studies 2.37 [1.53;3.65] 103 484
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 0.95[0.05; 17.06]14102%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 2.80[1.71; 4.60]7034677%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Pastuszak (Controls unexposed, NOS), 1993Pastuszak, 1993 1 1.41[0.55; 3.63]1912821%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 2.37[1.53; 3.65]1034840.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.37[1.53; 3.65]1034840%NAOzturk, 2016 Diav-Citrin, 2008 Pastuszak (Controls unexposed, NOS), 1993 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.37[1.53; 3.65]1034840%NAOzturk, 2016 Diav-Citrin, 2008 Pastuszak (Controls unexposed, NOS), 1993 3 Tags Adjustment   - No  - No 2.37[1.53; 3.65]1034840%NAOzturk, 2016 Diav-Citrin, 2008 Pastuszak (Controls unexposed, NOS), 1993 3 MatchedMatched 1.41[0.55; 3.63]19128 -NAPastuszak (Controls unexposed, NOS), 1993 1 Monotherapy   - no or not specified  - no or not specified 2.72[1.67; 4.43]843560%NAOzturk, 2016 Diav-Citrin, 2008 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.41[0.55; 3.63]19128 -NAPastuszak (Controls unexposed, NOS), 1993 1 All studiesAll studies 2.37[1.53; 3.65]1034840%NAOzturk, 2016 Diav-Citrin, 2008 Pastuszak (Controls unexposed, NOS), 1993 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6202

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.37[1.53; 3.65]1034840%NAOzturk, 2016 Diav-Citrin, 2008 Pastuszak (Controls unexposed, NOS), 1993 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.22[0.35; 4.18]1174 -NAPastuszak (Controls exposed to TCA), 1993 10.510.01.0