Fluoxetine updated on 07-01-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7941
R24021		 Sjaarda, 2020 Pregnancy loss (any loss occurring after hCG detection of pregnancy) early pregnancy prospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.66 [0.96;2.87] 8/26   143/662 151 26
ref
S7194
R20430		 Colvin, 2011 Terminations of Pregnancy (both spontaneous abortions and elective) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.43 [0.73;1.79] 105/394   24,313/119,840 24,418 394
ref
S6733
R25443		 Diav-Citrin, 2008 Intrauterine death (ETOP, Miscarriage, stillbirth, ectopic) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.24 [1.64;3.07] C 70/346   149/1,467 219 346
ref
Total 3 studies 1.83 [1.37;2.45] 24,788 766
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sjaarda, 2020Sjaarda, 2020 1.66[0.96; 2.87]1512622%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2011Colvin, 2011 1.43[0.73; 1.79]24,41839430%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Diav-Citrin, 2008Diav-Citrin, 2008 2.24[1.64; 3.07]21934648%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 30% 1.83[1.37; 2.45]24,7887660.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.83[1.37; 2.45]24,78876630%NASjaarda, 2020 Colvin, 2011 Diav-Citrin, 2008 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.83[1.37; 2.45]24,78876630%NASjaarda, 2020 Colvin, 2011 Diav-Citrin, 2008 3 Tags Adjustment   - No  - No 1.85[1.19; 2.86]24,63774062%NAColvin, 2011 Diav-Citrin, 2008 2   - Yes  - Yes 1.66[0.96; 2.87]15126 -NASjaarda, 2020 1 Monotherapy   - no or not specified  - no or not specified 2.08[1.59; 2.73]3703720%NASjaarda, 2020 Diav-Citrin, 2008 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.43[0.91; 2.24]24,418394 -NAColvin, 2011 1 All studiesAll studies 1.83[1.37; 2.45]24,78876630%NASjaarda, 2020 Colvin, 2011 Diav-Citrin, 2008 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.83[1.37; 2.45]24,78876630%NASjaarda, 2020 Colvin, 2011 Diav-Citrin, 2008 30.510.01.0