Fluoxetine - Medication and Pregnancy KB

Fluoxetine updated on 07-01-2025

Language disorders/delay

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18251 R76595	Suarez (Controls unexposed, discontinuers), 2022	Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age	2nd and/or 3rd trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy)	1.20 [0.99;1.44]	1,045/26,595 212/7,773	1,257	26,595		ref
S18252 R76603	Suarez (Controls unexposed, general pop), 2022	Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age	2nd and/or 3rd trimester	retrospective cohort (claims database)	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	1.15 [1.07;1.23] excluded (control group)	1,047/26,659 66,598/2,984,014	67,645	26,659		ref
S8015 R24400	Nulman (Controls exposed to TCA), 2002	Language, Verbal comprehension with the Reynell Developmental Language Scale at 15-71 months	throughout pregnancy	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No extrapolated (cont. endpoint) Monotherapy: SSRI only	4.35 [1.92;9.83] excluded (control group)	-/38 -/45	-	38		ref
S8016 R24406	Nulman (Controls unexposed, disease free), 2002	Language, Expression with the Reynell Developmental Language Scale at 15-71 months	throughout pregnancy	prospective cohort	unexposed, disease free	Adjustment: No extrapolated (cont. endpoint) Monotherapy: SSRI only	1.37 [0.59;3.19]	-/37 -/34	-	37		ref
					Total	2 studies	1.21 [1.01;1.45]		1,257	26,632
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, discontinuers; 2: Controls unexposed, disease free;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8015, 18252

S18251 R76595	Suarez (Controls unexposed, discontinuers), 2022	Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age (298)	2nd and/or 3rd trimester	unexposed, sick	1.20 [0.99;1.44]	1045/26595 212/7773
S18252 R76603	Suarez (Controls unexposed, general pop), 2022	Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age (298)	2nd and/or 3rd trimester	unexposed (general population or NOS)	1.15 [1.07;1.23]	1047/26659 66598/2984014
S8015 R24400	Nulman (Controls exposed to TCA), 2002	Language, Verbal comprehension with the Reynell Developmental Language Scale at 15-71 months (298)	throughout pregnancy	exposed to other treatment, sick	4.35 [1.92;9.83]	-9/38 -9/45
S8016 R24406	Nulman (Controls unexposed, disease free), 2002	Language, Expression with the Reynell Developmental Language Scale at 15-71 months (298)	throughout pregnancy	unexposed, disease free	1.37 [0.59;3.19]	-9/37 -9/34