Fluoxetine - Medication and Pregnancy KB

Fluoxetine updated on 07-01-2025

Persistent pulmonary hypertension

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13124 R50041	Marks (Controls exposed to Bupropion), 2021	Pulmonary Hypertension	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	3.52 [0.17;73.45] ^C	2/579 0/406	2	579		ref
S6076 R15815	Kieler, 2012	Persistent pulmonary hypertension of the newborn	2nd and/or 3rd trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	2.00 [1.00;3.80]	9/3,315 1,935/1,588,140	1,944	3,315		ref
S5934 R15194	Chambers, 2006	Persistent pulmonary hypertension of the newborn (PPHN)	2nd and/or 3rd trimester	nested case control	unexposed (general population or NOS)	Adjustment: No Matched Monotherapy: no or not specified	1.67 [0.37;7.49] ^C	3/7 374/1,206	377	7		ref
					Total	3 studies	1.99 [1.09;3.61]		2,323	3,901
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls exposed to Bupropion;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded