Fluoxetine updated on 07-01-2025

Genetic syndromes and microdeletions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6016
R15547		 Jimenez-Solem (Controls unexposed, NOS), 2012 Genetic syndromes 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.79 [0.25;12.76] 1/928   -/843,797 - 928
ref
Total 1 studies 1.79 [0.25;12.79] 0 928
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jimenez-Solem (Controls unexposed, NOS), 2012Jimenez-Solem, 2012 1 1.79[0.25; 12.76]-9280%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 Tags Adjustment   - Yes  - Yes 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 1 All studiesAll studies 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.79[0.25; 12.79]-928 -NAJimenez-Solem (Controls unexposed, NOS), 2012 10.510.01.0