Fluoxetine updated on 07-01-2025

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7354
R21617		 Jordan, 2016 Omphalocele 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.23 [1.04;17.19] C
excluded (exposition period) 		2/2,601   92/506,155 94 2,601
ref
S6242
R16501		 Malm, 2011 Omphalocele 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.97 [0.13;7.04] -/1,818   -/628,607 - 1,818
ref
S6157
R16114		 Louik, 2007 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.37 [0.02;6.06] C 0/61   127/5,926 127 61
ref
Total 2 studies 0.70 [0.14;3.56] 127 1,879
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Malm, 2011Malm, 2011 0.97[0.13; 7.04]-1,81866%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 0.37[0.02; 6.06]1276134%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.70[0.14; 3.56]1271,8790.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.13; 7.14]-1,818 -NAMalm, 2011 1 case control studiescase control studies 0.37[0.02; 6.06]12761 -NALouik, 2007 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.70[0.14; 3.56]1271,8790%NAMalm, 2011 Louik, 2007 2 Tags Adjustment   - No  - No 0.37[0.02; 6.06]12761 -NALouik, 2007 1   - Yes  - Yes 0.97[0.13; 7.14]-1,818 -NAMalm, 2011 1 Monotherapy   - no or not specified  - no or not specified 0.97[0.13; 7.14]-1,818 -NAMalm, 2011 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.37[0.02; 6.06]12761 -NALouik, 2007 1 All studiesAll studies 0.70[0.14; 3.56]1271,8790%NAMalm, 2011 Louik, 2007 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.70[0.14; 3.56]1271,8790%NAMalm, 2011 Louik, 2007 20.510.01.0